In this study, we focus on CALR, since several studies have revealed a connection between disruption of CALR function and various malignancies including myeloproliferative disorders [6], osteocarcoma [7], ovarian and non-small cell lung cancer [8], breast cancer [9], and Glioblastoma (GBM) [10]. The gene discussed is CALR; the disease is non-small cell lung carcinoma.