MYC and colorectal cancer: In particular, a recent work reported that the long isoform of colorectal cancer associated transcript 1 (CAAT1-L, also known as CARLo-5), which is transcribed from 8q24 region and highly expressed in colorectal cancer [13,111], is involved in the formation of regulatory chromatin loops between the MYC promoter and its enhancer thus controlling MYC expression [14].