EZH2 and neoplasm: Suppression of CRNDE expression in CRC cells inhibits cell proliferation and results in the upregulation of the tumor suppressors DUAP5 and CDKN1A. Similarly to HOTAIR, it has been demonstrated that CRNDE interacts with PCR2 via EZH2 and contributes to establish a silenced chromatin state on promoters of the two genes, therein promoting tumor development [71].