CDKN2A and leukemia: Notably, this dynamic regulation failed in many neoplastic transformations such as in neoplastic epithelial tissues [9], oesophageal squamous cell carcinoma [10] and leukaemia leukocytes [11,12] where ANRIL overexpressed and as a consequence, a most robust and stable silencing of the INK4B-ARF-INK4A locus occurs.