LATS1 and neoplasm: A tumor-suppressing pathway called the Salvador–Warts–Hippo (SWH) pathway, was revealed by genetic studies in Drosophila which have identified LATS as a central mediator.[26,27] Also a critical factor in the regulation of organ size in Drosophila melanogaster and mamma is the SWH pathway.[28,29] Further, implicated in the genesis of multiple human cancers is the deregulation of SWH pathway activity.[30–32] LATS1 plays a suppressor role in some tumors.