Importantly, the finding that signalling variation in NSCLC relates to histopathology matches our identification of histotype‐specific immune microenvironments in KL‐driven NSCLC 22, and, together with reported differences in energetic dependencies 31, 32 and epigenetic signatures 33, warrants consideration of histotype‐specific phenotypes in treatment decisions. Here, KL is linked to non-small cell lung carcinoma.