AKT1 and neoplasm: Thus, both murine and human NSCLCs showed marked differences in signalling profiles, with an important part, but far from all, of this intertumour variability being explained by histotype: SRC, and even more so PI3K–AKT pathway activity, is more frequently detected in ASC histotype tumours, particularly in the SCC regions, whereas MAPK activity is more frequently detected in AC histotype tumours.