Tumours are initiated from different progenitors, using adenoviruses that predominantly target Cre recombinase to either alveolar type II cells expressing surfactant protein C (Ad5‐SPC‐Cre), or to bronchiolar club cells expressing club cell antigen 10 (Ad5‐CC10‐Cre) 19, 20. The gene discussed is SFTPC; the disease is neoplasm.