Here we report a comparative study investigating the effect of recombinant BMP-2 homodimer proteins on osteogenic differentiation of human dental pulp stem cells (DPSC) isolated from the pulp tissue of healthy human wisdom teeth and two commonly used preosteoblast cell lines, namely Saos-2 osteosarcoma cells and human embryonic palatal mesenchymal preosteoblast cells (HEPM). This evidence concerns the gene BMP2 and osteosarcoma.