Several factors such as transforming growth factor (TGF)‐β1 10, 14, osteopontin 15, 78 kDa glucose‐regulated protein (GRP78) 13, and basic fibroblast growth factor (bFGF) 31 were highly enriched in tumor cell‐conditioned medium and were required for inducing CAF‐like differentiation of BM‐MSCs. The gene discussed is SPP1; the disease is neoplasm.