Several factors such as transforming growth factor (TGF)‐β1 10, 14, osteopontin 15, 78 kDa glucose‐regulated protein (GRP78) 13, and basic fibroblast growth factor (bFGF) 31 were highly enriched in tumor cell‐conditioned medium and were required for inducing CAF‐like differentiation of BM‐MSCs. This evidence concerns the gene HSPA5 and neoplasm.