In the current study, we found that CRC tissue samples with high levels of DJ‐1 or P‐AKTs473 lacked PTEN protein, whereas DJ‐1‐knockdown colon cancer cells demonstrated an increase in PTEN expression that, in contrast, was decreased in DJ‐1‐overexpressing cells compared with that in the control. Here, PARK7 is linked to malignant colon neoplasm.