Furthermore, the expression of PTEN was increased, whereas that of DJ‐1 and P‐AKTs473 decreased in tumors derived from DJ‐1‐knockdown cells compared to those derived from control cells (Fig. 6D), suggesting that the DJ‐1/PTEN/AKT pathway is involved in the progression of colon cancer cells in vivo. This evidence concerns the gene PARK7 and malignant colon neoplasm.