The results revealed that DJ‐1‐knockdown SW480 cells invaded and migrated into the lower chamber slower than control cells (Fig. 3B, P < 0.05), Furthermore, the number of invading and migrating CRC cells transfected with OE‐DJ‐1 was increased compared with that of mock cells (Fig. 3C, P < 0.05). This evidence concerns the gene PARK7 and colorectal carcinoma.