PRMT5 knockdown inhibits proliferation and cell cycle transition from the G1 to S phase, and a large number of corroborating studies have shown that PRMT5 levels are elevated in various cancers, including gastric, colorectal, lung, lymphoma, leukemia, and liver cancers 5, 8, 9, 10, 11. Here, PRMT5 is linked to leukemia.