PIM3 and cancer: Pim kinases are expressed in normal and cancer cells and play a role in the cell growth/survival.23, 24, 44 Thus, assuming that knockdown of endogenous Pim‐3 does not interfere with lipid accumulation, AZD1208 largely inhibits adipogenesis, enhances Pim‐3 protein and increases cell survival in differentiating 3T3‐L1 cells on day 8, the drug's anti‐adipogenic effect is likely to be the Pim‐independent, and the up‐regulated Pim‐3 by AZD1208 may favour survival/growth of 3T3‐L1 cells at the late stage of differentiation.