VEGFA and cancer: While the trend of TSP‐1 expression in cancers remains elusive, VEGF levels (plasma, serum, platelet, tissue) tend to be up‐regulated in most cases.105 Published data so far have not suggested any correlation between circulating levels of VEGF and TSP‐1 in patients with cancer (Table 4), but elevated circulating VEGF expression alone is a well‐established prognostic marker of decreased patient survival in several types of cancer.106 Some previous studies have tried to elucidate the potential relationship between VEGF and TSP‐1 expressions within tumours.