Previous studies conducted in China, Japan and Korea demonstrated that ALDH2 Glu504Lys variant was closely related to ACS or myocardial infarction (MI) and that the mutant genotypes (*2/*2 and *1/*2) were independent risk factors for ACS in East Asians.2, 3, 4 Moreover, a genome‐wide association study of common SNPs confirmed that aldh2 is the susceptibility gene of coronary artery disease (CAD).5 However, to date, there are still lacking researches about the relationship between the Glu504Lys variant and prognosis of ACS. This evidence concerns the gene ALDH2 and myocardial infarction.