For gene‐gene interactions, the top pair MST1‐JAK2 had significant P‐values in the original and validation data set (original: P = 9.44 × 10−11; validation IBD: P = 7.28 × 10−5; validation Crohn's disease: P = 4.81 × 10−3). Here, JAK2 is linked to inflammatory bowel disease.