In this study, by SKAT analysis and W‐test, even though NOD2 SNPs individually were not significantly associated with Crohn's disease, co‐occurrence of NOD2 rs2111234 and MST1 rs144982232, JAK2 rs1159782 or VDR rs11574129 attained a significant association. The gene discussed is NOD2; the disease is Crohn disease.