High doses of TBBPA may in part promote uterine tumors in rats by promoting growth of cells with pre‐existing mutations in the p53 tumor suppressor gene driven by increased estrogen‐dependent cellular proliferation, or through selective proliferation of these mutations caused by reactive quinone intermediates (Lai et al., 2015; NTP, 2014). The gene discussed is TP53; the disease is tumor of uterus.