CAFs comprise a highly heterogeneous cell population with different CAF subtypes shown to exert either tumor‐promoting or tumor‐inhibitory effects in PCa.9In vitro data herein demonstrating that Nox4 plays a central role in paracrine‐mediated pro‐proliferative and promigratory effects of activated fibroblasts on PCa cells strongly suggest that Nox4 inhibition will exert antitumorigenic effects. This evidence concerns the gene NOX4 and neoplasm.