Genes encoding the ETS family of transcription factors (including ERG) are frequently rearranged in PCa with ERG overexpression shown to drive invasion and metastasis.31 Thus, the significant increase in stromal Nox4 expression in high‐grade and ERG‐fusion‐positive PCa versus low‐grade and ERG‐fusion‐negative PCa, respectively, together with our previous finding that total Nox4 mRNA levels correlate with biochemical relapse19, 20 implicate an active role of stromal Nox4 in PCa progression. Here, ERG is linked to posterior cortical atrophy.