cfDNA was analyzed for the presence of p.T790M mutation and patient-specific EGFR activating mutations known from primaries by BEAMing in a cohort of 23 advanced NSCLC cases progressive after EGFR-TKI treatment and 21 advanced NSCLC, EGFR-TKIs-naive patients (99). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.