A mutation in codon 249 of TP53 [NM_000546.5 (TP53):c.747G>T (p.Arg249Ser)], common after dietary exposure to the high levels of aflatoxin B1, was detected in plasma of 4/8 patients at least 1 year before initial diagnosis of HCC (130). The gene discussed is TP53; the disease is hepatocellular carcinoma.