Thus, crucial role of anti-DNA in SLE pathogenesis, association of its production with T cell engagement, its involvement along with CCR6+ Th cells in kidney impairment, and differential clinical course between anti-DNA positive and negative patients, prompted us to investigate the differences in Th cell distribution between anti-DNA+ and anti-DNA− SLE patients. The gene discussed is CCR6; the disease is systemic lupus erythematosus.