However, no significant difference was observed in the distribution of CCR6+ Th22 (P = 0.4675) (Fig. 2C) and CCR6+CCR4+CXCR3+ Th cells (P = 0.2158) (Fig. 3B) between anti-DNA+ and anti-DNA− SLE patients. This evidence concerns the gene CCR4 and systemic lupus erythematosus.