SIM1 and obesity due to melanocortin 4 receptor deficiency: As previously mentioned, SH2B1, SIM1, PTBP2, PRLH, CAPN10, ACP1, TMEM18, EHMT1, and GNB3 are relevant candidate and known genes for obesity within these regions (Fig. 6), and POU3F2 [20], HDAC4 [50], MYT1L [52], and RAI1 [53] were also candidate genes identified in these loci. Moreover, our gene prioritization analysis identified 20 new genes of interest to obesity overlapping these CNVs, among which we highlight the potential importance of TAS1R3, encoding a taste receptor differentially expressed in obese mice [54].