Notably, several known and candidate genes that have previously been implicated in syndromic obesity were retrieved by this candidate gene approach, including SIM1 [48], SH2B1 [49], PTBP2 [38], PRLH and CAPN10 [50], ACP1 and TMEM18 [12], EHMT1 [51], and GNB3 [17]. This evidence concerns the gene GNB3 and obesity due to melanocortin 4 receptor deficiency.