As expected, Fgl2-deficient colonic macrophages isolated from DSS-treated mice produced higher levels of the M1 effector molecule IL-1β, but lower levels of the M2 polarization markers MR, Arg-1, and Fizz1 (Figure 4C) in DSS colitis than macrophages from DSS-treated WT mice. This evidence concerns the gene NR3C2 and colitis.