Mammalian TBK1 is constitutively expressed and unchanged during viral infection (35, 74), but expression of fish TBK1 can be induced by stimulation of various viral/bacterial PAMPs (PMA, poly I:C, β-glucan, and LPS) and viral infection (SVCV and GCRV) (36–39). The gene discussed is TBK1; the disease is viral infectious disease.