When TLR2-p, a TLR2 transmembrane domain-derived peptide, interacted directly with TLR2 within the membrane, thereby inhibiting TLR2–TLR6/1 activity, the result was significantly ameliorated dextran sodium sulfate (DSS)-induced colitis, as assessed by histology, colonoscopy, and body weight measurements (35). This evidence concerns the gene TLR2 and colitis.