ITGAX and Autoimmunity: While in all of the many rodent models of autoimmunity studied (24), decreased rather than increased autoimmune pathology has been observed as a result of CD28SA treatment, we nevertheless directly tested this possibility by injecting 3 × 104 CFSE-labeled OVA/Kb-specific OT-I and 6 × 104 OVA-IAb-specific OT-II cells into CD11c-DOG mice which express OVA in dendritic cells (20) or, as a control, into WT C57BL/6 mice.