P2RY12 and Arterial thrombosis: Regardless, although an antagonist may not completely inhibit the action of P2Y12 or account for other functions of P2 receptors, it is clear that inhibition of P2Y12 can be beneficial in limiting thrombus growth in arterial thrombosis and secondary prevention of ischemia (Andre et al., 2003; van Gestel et al., 2003).