BACE1 and Alzheimer disease: Gong et al. (2013) have shown that nicotinamide activity depends also on its ability to induce degradation of Bace1. Recently published clinical trials showed safety, but no effect of nicotinamide on cognitive function of AD patients (Phelan et al., 2017). Despite this, nicotinamide anti-AD activity is still studied and further trial is currently ongoing (Grill, 2017).