CLU mutations that are suggested as causal for AD affect hippocampal connectivity (Zhang et al., 2015), white matter integrity in several brain regions (Braskie et al., 2011), cortical gray matter volume (Stevens et al., 2014), as well as working memory (Stevens et al., 2014) and episodic memory performance (Barral et al., 2012). Here, CLU is linked to Alzheimer disease.