Bcl-2 has been shown to be downregulated in spinal cord of ALS patients and in the G93A mutant SOD1 mouse, while Bax has been shown to be upregulated (Mu et al., 1996; Ekegren et al., 1999; Vukosavic et al., 1999). The gene discussed is BAX; the disease is amyotrophic lateral sclerosis.