All Akt isoforms are involved in the induction and progression of human cancer (Altomare and Testa, 2005), but the Akt1 and Akt2 isoforms play different roles in certain cancers (Hutchinson et al., 2004; Irie et al., 2005; Maroulakou et al., 2007; Dillon et al., 2009): Akt1 is critical for cancer induction and Akt2 for metastatic dissemination. The gene discussed is AKT2; the disease is cancer.