Further, intense desmoplastic activity was observed in intermediate and high-grade PCa, which also showed increased expression of vimentin, IGF-1, MMP-2, FGF-2, c-Myc, PSCA and Era [19], and an intense reactive stroma has been reported to distinguish benign from malignant prostatic tissue [20]. The gene discussed is IGF1; the disease is posterior cortical atrophy.