MORC2 and neuropathy: Indeed, this is what we found through analysis of the three neuropathy-associated MORC2 mutants: T424R, which hydrolyzes ATP more rapidly than wild-type, leads to less efficient HUSH silencing, whereas S87L and R252W, which hydrolyze ATP more slowly than wild-type, match or hyperactivate wild-type HUSH silencing (Fig. 5).