Although the interplay between pyroptosis and enterovirus infection needs further investigation, we postulate here that pyroptosis induced by enterovirus infection may not lead to the establishment of antiviral status to eliminate the intracellular EV71 or CVB3, since both viruses have been demonstrated to evade antiviral immunity by cleaving the proteins involved in innate immunity such as mitochondrial antiviral signalling protein (MAVS), melanoma-differentiation-associated (MDA5), and retinoic acid-inducible gene I (RIG-I) with viral proteases64–66. Here, RIGI is linked to enterovirus infectious disease.