However, study by Rajan, J. V., et al. indicated that pyroptosis or caspase-1 related inflammation may not determine the outcome of viral infection, since there was no difference for the survival rate between wild type mice and caspase-1 knockout mice infected with encephalomyocarditis virus (EMCV), another RNA virus in Picornaviridae family45. The gene discussed is CASP1; the disease is viral infectious disease.