Also, lncRNAGAS5 acted as a tumor suppressor in hepatocellular carcinoma through negative regulation of miR-21 to up-regulate its targets programmed cell death 4 (PDCD4) and phosphatase and tensin homologue (PTEN), resulting in inhibition of cancer cell migration and invasion19. This evidence concerns the gene PDCD4 and hepatocellular carcinoma.