To highlight the functional enhancement in the T cell compartment, we demonstrated elevated levels of cytolytic T cell effector mechanisms, including the elevated level of Granzyme b production by CD8+T cells and enhanced cellular killing, after the direct interaction of murine metastatic prostate cancer cells with CD8+T cells and the activated ILC2 cells (Fig. 7). This evidence concerns the gene GZMB and Familial prostate cancer.