For example, in contrast to our studies, Wang et al., (2016) teaches that IL-33 signaling fuels the growth of human lung cancer, however, the authors only examined IL-33 expression in isolated primary tumour cells, not in metastatic tumour cells isolated from distal organs, thereby overlooking the difference in IL-33 expression metastatic versus primary tumour cells. The gene discussed is IL33; the disease is lung cancer.