Interestingly, reduced A20 expression has been documented in cells from patients with several autoimmune diseases, and reduced A20 expression and polymorphisms in TNFAIP3 have been associated with response to tumor necrosis factor (TNF)-blocking therapies in rheumatoid arthritis (RA), psoriasis, and Crohn’s disease9,15. Here, TNFAIP3 is linked to autoimmune disease.