A20 loss-of-function mutations result in a Behcet’s syndrome-like phenotype11, whereas genome-wide association study-identified SNVs in noncoding regions of the TNFAIP3 locus are associated with a variety of distinct autoimmune diseases, including SLE, RA, inflammatory bowel disease (IBD), type I diabetes mellitus, and psoriasis. The gene discussed is TNFAIP3; the disease is rheumatoid arthritis.