Most relevant for this study, deletion of A20 in B cells results in a mild autoimmune syndrome with increased germinal center formation and autoantibody production; in dendritic cells results in IBD, spondyloarthritis and a protean autoimmune syndrome that resembles SLE; and in myeloid cells results in erosive inflammatory arthritis involving the paws33–36,39. The gene discussed is TNFAIP3; the disease is inflammatory bowel disease.