The “TT>A” allelic variant (tandem polymorphic dinucleotides rs148314165 and rs200820567; the risk allele is termed TT>A) located 41.6 kb downstream of the TNFAIP3 TSS is located within the most highly replicated ≈100 kb risk haplotype for autoimmune diseases. The gene discussed is TNFAIP3; the disease is autoimmune disease.