Next, we combined the data available in two GEP data sets (#GSE66293 and #GSE47552) as previously described13 and found that RHOU expression is significantly and negatively modulated with disease progression, being over-expressed in BM PCs from MGUS patients and down-modulated in BM PCs from most MM patients (Fig. 1b left panel). The gene discussed is RHOU; the disease is Miyoshi myopathy.