SETBP1 mutations have been identified in nearly 25% of aCML patients and have been associated with higher white blood cell count at diagnosis and inferior survival;129 they have also been identified, to a lesser extent, in MDS/MPN unclassified (10%)129, CMML (14.5%), and AML (<1%)130. This evidence concerns the gene SETBP1 and chronic myelomonocytic leukemia.