In a critical and comprehensive study, Elliott et al. evaluated the prognostic relevance of a number of factors including age, LDH, cytopenias, splenomegaly, bilirubin levels, and genetic variables such as SETBP1, ASXL1 and CSF3R mutations in 14 CSF3R-mutated CNL cases18. The gene discussed is SETBP1; the disease is chronic neutrophilic leukemia.