PPARA and diabetes mellitus: In the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study, PPAR-α agonist fenofibrate treatment was associated with a statistically non-significant trend towards a reduction in the 5-year CVD risk of 14.5 to 13.1%, representing a proportional risk reduction of 11% (adjusted HR 0.89 (95% CI 0–21%), P = 0.052; absolute risk reduction 1.4%).