Fittingly, IFNAR1 gene polymorphisms have been associated with disease severity and progression to cerebral malaria, especially in children (33, –, 35), and Ifnar1−/− mice showed significant protection against the development of experimental cerebral malaria (ECM) with a reduced accumulation of CD8+ T cells (35, –, 37). The gene discussed is IFNAR1; the disease is cerebral malaria.