TSN and cancer: Subsequently, a positive correlation between carcinogenesis and TSN overexpression was discovered in different types of cancers, including colon cancer (Tsuchiya et al. 2007), hepatocellular carcinoma (Yoo et al. 2011), breast cancer (Blanco et al. 2011; Wan et al. 2014), prostate cancer (Kuruma et al. 2009), and malignant glioma (Emdad et al. 2015).