Although all types of pituitary adenomas have been described with germline AIP mutations, patients with such mutations typically have young-onset growth hormone (GH)-secreting or GH-secreting and prolactin-secreting tumours with generally poor responsivity to conventional treatment, and aggressive behaviour compared with those with no recognised mutation,7 8 often requiring repeated surgery and radiotherapy and therefore needing close surveillance.7 13 14. The gene discussed is GH1; the disease is neoplasm.