HLA-DRB5 and cancer: Variants were observed in several genes known to be important for immune function, including splice site SNPs in RAG1, HLA-DRB1, and HLA-DRB5, as well as a nonsense mutation in HLA-DRB5. Several cancer-relevant genes were also observed: splice-site alterations in DDX3X (Dahlin et al. 2015) and MAD2L2 (alias: REV7) (Boersma et al. 2015; Xu et al. 2015) and in-frame insertions in MNX1 (Das 2016) and ZFHX3 (Mabuchi et al. 2010).