Pro-inflammatory nature of the cardiovascular disease can be explained by this fact that almost in all of the atherosclerosis processes inflammatory molecules are involved; initiation of the atherosclerosis by numerous triggers including saturated fatty acids, hypertension and obesity stimulates the expression of adhesion molecules like vascular cell adhesion molecule − 1 (VCAM-1) in endothelial cells; VCAM expression initiates by means of oxidized lipids by nuclear factor kappa B, IL-1β and TNF-α [13]. This evidence concerns the gene VCAM1 and obesity due to melanocortin 4 receptor deficiency.