It has been proposed that high-inflammatory diet characterized by (a) increased consumption of refined high-glycemic load carbohydrates, (b) increased consumption of refined vegetable oils rich in omega-6 fatty acids, and (c) decreased consumption of long-chain omega-3 fatty acids leads to entry of a diet with high glycemic load into the blood stream and high production of insulin is responsible for silent inflammation in diabetes [51]. The gene discussed is INS; the disease is diabetes mellitus.