Interestingly, Rab35 was identified as a potential serum biomarker for PD through the analysis of proteomic profiles of PD patients, and Rab35 was also elevated in the substantia nigra obtained from multiple PD animal models, including MPTP-, rotenone-treated mice, and LRRK2-R1441C or -G2019S transgenic mice [48]. The gene discussed is LRRK2; the disease is Parkinson disease.