TFAP2C and colorectal carcinoma: To determine the stimulatory roles of TFAP2C in the chemotherapeutic resistance of CRC, we first constructed TFAP2C-stably expressing SW480 and HCT116 CRC cell lines by ectopically overexpressing TFAP2C and endogenously knocking down TFAP2C via retrovirus infection (Additional file 9: Figure S4A and B).