TFAP2C and colorectal carcinoma: Furthermore, our results demonstrated that silencing TFAP2C dramatically reduced the cell proliferation ability via CCK-8, colony formation and anchorage-independent growth assays; however, upregulating TFAP2C had no obvious effect on the proliferation ability of CRC cells (Additional file 9: Figure S4C-E), suggesting that overexpression of TFAP2C promotes chemoresistance of CRC cells to 5-FU independent on the effects of TFAP2C on cell proliferation.