Moreover, cellular fractionation and western blotting analysis revealed that overexpression of TFAP2C reduced the p-MST1/2, p-LATS1 and p-YAP levels, increased cytoplasmic and nuclear YAP and TAZ levels, and had no effect on total expression level of MST1/2 and LATS1 in CRC cells; however, silencing TFAP2C yielded an opposite effects (Fig. 6e and f). The gene discussed is LATS1; the disease is colorectal carcinoma.