As shown in Additional file 16: Figure S11A-F, TFAP2C, YAP and TAZ expression levels were upregulated in resistant CRC tissues (T1–4) compared with that in sensitive CRC tissues (T5–8); conversely, p-MST1/2 and p-LATS1 expression were reduced in resistant CRC tissues. Here, MST1 is linked to colorectal carcinoma.