While Hippo signaling is absent, unphosphorylated YAP1/TAZ enters the nucleus and induce the transcriptional activity of TEA domain (TEAD) family members (TEAD1–TEAD4) as the transcriptional co-activators, which further transcriptionally upregulate multiple downstream effectors to exert a pleiotropic role in tumor progression and metastasis [23–25]. Here, YAP1 is linked to neoplasm.