Importantly, we found 6 variants, including three PDX1 variants P33T [42], E224K [12, 43], P242L [44], HNF4A V169I [12, 45], BLK A71T [12, 46] and NEUROD1 H241Q [12, 47], previously reported to be linked to MODY, to occur at a similar frequencies in the MODY cases and the general population. The gene discussed is PDX1; the disease is MODY.