Zhou et al. reported that the homozygote of the minor allele of the rs1801133 polymorphism of the MTHFR (TT) gene was associated with reduced colorectal cancer risk [38], and low folate and high alcohol intake was more harmful for colorectal cancer incidence in the MTHFR wild type (CC) group than in TT group [39–44]. The gene discussed is MTHFR; the disease is colorectal cancer.