KMT2A and leukemia: Normal mouse bone marrow progenitor cells were transduced with MSCV-GFP-MLL-AF9 or MSCV-GFP-MLL-AF9 plus MSCV-miR-375 and then were plated onto methylcellulose medium, because MLL-AF9 can rapidly transform normal hematopoietic stem cells into leukemia stem cells [28].