Interestingly, the Ki-67 proliferation index of HPV-positive samples (median: 69.5%, interquartile range: 27.0%) with nuclear or cytoplasmatic p16INK4a staining ≥50% was significantly higher compared to the corresponding areas of HPV-negative tumor samples (median: 47.0%, interquartile range: 26.0%; p = 0.004). This evidence concerns the gene CDKN2A and neoplasm.