In esophageal cancer, CDKN2A, RPRM (reprimo), CDKN1C (cyclin dependent kinase inhibitor 1C), TP73 (tumor protein p73), RUNX3 (runt related transcription factor 3), CHFR (checkpoint with forkhead and ring finger domains), MGMT, TIMP3 (TIMP metallopeptidase inhibitor 3), and HPP1 (hyperpigmentation, progressive, 1) comprise a marker panel showing decreased methylation in radiation-responsive patients. The gene discussed is RUNX3; the disease is esophageal cancer.