In esophageal cancer, CDKN2A, RPRM (reprimo), CDKN1C (cyclin dependent kinase inhibitor 1C), TP73 (tumor protein p73), RUNX3 (runt related transcription factor 3), CHFR (checkpoint with forkhead and ring finger domains), MGMT, TIMP3 (TIMP metallopeptidase inhibitor 3), and HPP1 (hyperpigmentation, progressive, 1) comprise a marker panel showing decreased methylation in radiation-responsive patients. This evidence concerns the gene TP73 and esophageal cancer.