Although there are potentially many mechanistic explanations for a phenotype of hypertension with low renin and aldosterone, a recent clinical trial demonstrated that treating African patients with a low-renin and aldosterone phenotype using ENaC inhibitors resulted in the most effective control of blood pressure [78], a finding that extended genetic studies demonstrating a high prevalence of SCNN1B variants in individuals of African descent with LRH [79]. Here, REN is linked to hypertensive disorder.