In a recent study, we observed that lower cortisone levels (in combination with higher F/E ratio) were strongly associated with higher MR activity (lower renin activity and higher urinary potassium excretion) in patients suspected to have mild or non-classical AME (Tapia-Castillo, Baudrand, Vaidya, et al. personal communication). Here, NR3C2 is linked to apparent mineralocorticoid excess.