According to the information deposited in the databases of the International Cancer Genome Consortium (ICGC), it seems that approximately 300 splicing-related genes are mutated in all types of cancer, where the most frequently mutated genes include several hnRNP (NOVA1, hnRNP M, hnRNP C, hnRNP A2/B1, hnRNP F, and RALY) and SR proteins (SRSF4, RBM39, Tra2α, and Tra2β) together with SR-protein kinases (SRPK1 and SRPK2) and RBM proteins (RBM4 and RBM5). The gene discussed is RALY; the disease is cancer.