FOLH1 and neoplasm: The lower tumor affinity of DOTA-conjugated compounds led to the development of 1,4,7,10-tetraazacyclododececane,1-(glutaric acid-4,7,10-triacetic acid (DOTAGA)-conjugated compounds [43], including PSMA-I&T, which also incorporates a lipophilic peptidic linker to improve the interaction with PSMA, and therefore enhance tumor uptake.