The high sensitivity of 68Ga-PSMA PET/CT, coupled with the increased expression in higher grade tumors, guided intra-prostatic biopsy has shown in several small studies that 68Ga-PSMA avidity correlates well with gross tumor volume as detected by multiparametric MRI and voxel based determinants directly matched to histopathological specimens [81,82]. This evidence concerns the gene FOLH1 and neoplasm.