TBX21 and breast neoplasm: Infiltration of >30% of breast tumors by CD8+, TBET+ T-cells (T-box transcription factor TBX21, a marker of type 1 T-cells) and more generally, Th1 type cells, can predict improved DFS [27], while the presence of Th2 and FoxP3+ are more generally associated with worse survival rates [28].